Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing.
MouseOther
Model: Acutely injured intestinal mucosa and in vivo colitis injury models relevant to inflammatory bowel disease
Targeted inhibition of miR-23a and miR-155 in cultured intestinal epithelial cells and in acutely injured mucosa decreased the detrimental effects of neutrophils and enhanced tissue healing responses.
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