Human liver stem cells attenuate concanavalin A-induced acute liver injury by modulating myeloid-derived suppressor cells and CD4 T cells in mice.
MouseChemical/toxinC57BL/6Malen = 66 mice: normal n=6, concanavalin A n=30, HYX1 plus concana…Intraperitoneal injection2.0 x 10^6 cellsCells given 3, 6, 12, 24 or 48 h before concanavalin A challenge
Model: Concanavalin A-induced acute liver injury, 12 mg/kg via tail vein
HYX1 transplantation 6 or 12 h before concanavalin A lowered ALT, AST and total bilirubin and reduced necrosis and inflammatory infiltration, with increased myeloid-derived suppressor cells, fewer CD4 T cells and a shift towards IL-10; no protection was seen when cells were given 48 h beforehand.
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