Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder.
RatOtherSprague-DawleyMalePretreatment at the beginning of cardiopulmonary bypass
Model: Rat model of cardiopulmonary bypass causing cardiac injury and acute glucose metabolic disorder
AICAR pretreatment activated AMPK, increased AS160 phosphorylation and membrane GLUT4, improved myocardial glucose uptake and reduced markers of cardiac injury after bypass, with the benefit abolished by mutant AS160-4P.
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