Corilagin alleviates acetaminophen-induced hepatotoxicity via enhancing the AMPK/GSK3beta-Nrf2 signaling pathway.
MouseChemical/toxinC57BL/6 wild-type and Nrf2 knockoutMaleIntraperitoneal15, 30 or 60 mg/kgPretreatment, with the final dose 1 h before acetaminophen challenge
Model: Acetaminophen-induced acute liver failure by single intraperitoneal injection, 900 mg/kg for survival endpoints and 400 mg/kg for tissue endpoints
Corilagin pretreatment reduced mortality and serum ALT and AST, limited necrosis, lowered myeloperoxidase and malondialdehyde and restored superoxide dismutase and the GSH to GSSG ratio, with protection largely abolished in Nrf2-deficient mice.
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