PRECLINICAL PUBLICATION · 2019

Protease-activated receptor-2 regulates glial scar formation via JNK signaling.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Protease-activated receptor-2 inhibitor and activator, with the JNK activator anisomycin and JNK inhibitor SP600125

PMID 30628825 ↗2019Mixed findings

Protease-activated receptor-2 regulates glial scar formation via JNK signaling.

RatSpinal cord injuryCompressionSprague-DawleyFemale

Model: Rivlin and Tator acute extradural clip compression injury model of severe spinal cord injury

Protease-activated receptor-2 activity promoted glial scar formation and reduced surviving neurons, worsening functional outcome via JNK signalling, so its inhibition was beneficial while its activation was harmful.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.5. Machine-extracted fields require source verification.