Neuroprotection by Paeoniflorin against Nuclear Factor Kappa B-Induced Neuroinflammation on Spinal Cord Injury.
RatSpinal cord injuryCompressionSprague-DawleyMale and femalen = 30 per group across sham, injury and paeoniflorin groups; t…Intraperitoneal20 mg/kg/dayStarted the day after surgery
Model: T9 laminectomy followed by spinal cord crush with a vascular clip at 15 g force for 1 min
Paeoniflorin improved hindlimb locomotor recovery at 7 and 14 days, reduced histopathological damage and neuronal loss, and suppressed NF-kappaB nuclear translocation with lower iNOS, COX-2, Nogo-A, Bax and cleaved caspase-3.
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