AP-1 (Activated Protein-1) Transcription Factor JunD Regulates Ischemia/Reperfusion Brain Damage via IL-1beta (Interleukin-1beta).
MouseIschaemia-reperfusionCerebral (MCAO/stroke)Wild type (strain not stated)MaleAnti-IL-1beta monoclonal antibody given on reperfusion
Model: 45 min transient middle cerebral artery occlusion followed by 24 h reperfusion
JunD knockdown increased infarct size, worsened neurological function and raised brain IL-1beta and systemic inflammation, and these deleterious effects were reversed by an anti-IL-1beta antibody.
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