Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache.

PMID 30624345 ↗2019Mixed findings

Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache.

RatTBIWeight-drop / impact-accelerationSprague-DawleyMalen = 8 to 12 per groupIntraperitoneal for bothCompound 48/80 escalating 0.5, 1, 2 and 4 mg/kg as 0.1% w/v…Compound 48/80 given prophylactically, with injury induced 4 days after the las…

Model: Mild closed head injury by weight drop, a 250 g projectile dropped from 80 cm onto the centre of the head

Mast cell granule depletion before injury did not change acute cephalic mechanical hypersensitivity but abolished later glyceryl trinitrate-evoked latent sensitisation, and the anti-CGRP antibody did not reduce injury-evoked meningeal mast cell degranulation.

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Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache.

Evidence by therapy association

Intact mast cell content during mild head injury is required for development of latent pain sensitization: implications for mechanisms underlying post-traumatic headache.