The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling.
MouseChemical/toxinBalb/cMalen = 108 mice in six groups of 18, with 6 sacrificed per time po…Oral, dissolved in 1% DMSO20 or 40 mg/kg in vivo; 15 and 30 microM in vitroPretreatment for 5 days before concanavalin A injection
Model: Concanavalin A-induced acute autoimmune hepatitis, 25 mg/kg via tail vein
Levo-tetrahydropalmatine pretreatment dose-dependently lowered transaminases, necrosis, TNF-alpha and IL-6, apoptosis and autophagy markers, and TRAF6 and phospho-JNK.
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