Inflammatory cytokines are involved in dihydrocapsaicin (DHC) and regional cooling infusion (RCI)-induced neuroprotection in ischemic rat.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Sprague-DawleyMaleIntraperitoneal injection for dihydrocapsaicin; intra-arterial infusion of 6 ml cold saline at 4 degrees C for regional coolingAfter middle cerebral artery occlusion
Model: Middle cerebral artery occlusion for 2 h using an intraluminal hollow filament, followed by reperfusion
The combination of dihydrocapsaicin and regional cooling infusion reduced infarct volume and neurological deficit (p < 0.05), decreased blood brain barrier leakage and pro-inflammatory cytokines IFN-gamma, IL-2 and TNF-alpha, and increased protective cytokines IL-4 and IL-10 in the peri-infarct are…
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