Plasma-based biomaterials for the treatment of cutaneous radiation injury.
MouseRadiationBALB/cMalen = 22 per group, total 44; 5 animals lost to anaesthesia death…Topical, followed by bandaging0.3 ml of paste per application, spread as a thin film over…Initiated within 24 h following radiation exposure
Model: Cutaneous radiation injury: a 2 cm diameter circle of dorsal skin exposed through a lead shield to a single dose of 35 Gy using an RS 2000 biological irradiator with 165 kV x-rays
Wound closure was significantly better with the plasma-based biomaterial at 12, 13 and 14 weeks post-maximum wound area (14.1 +/- 5.2% vs 34.3 +/- 6.1%; 12.1 +/- 3.9% vs 29.2 +/- 7.0%; 5.7 +/- 3.7% vs 20.7 +/- 8.2%, all p < 0.05). Peak wound size did not differ (p = 0.08). Chronic wounds occurred i…
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