New therapeutic strategy of hinokitiol in haemorrhagic shock-induced liver injury.
MouseHaemorrhage/shockControlledC57BL/6Malen = n = 4 per group across three groups (sham, haemorrhagic sho…Intravenous1.7 mg/kg in vivo; 2, 5 and 10 micromol/L in isolated prima…Given at resuscitation, that is 60 min after onset of haemorrhagic shock
Model: Controlled haemorrhagic shock to mean arterial pressure of 30 plus or minus 2 mm Hg maintained for 60 min, followed by resuscitation with Lactated Ringer's solution at three times the shed blood volume
Haemorrhagic shock with resuscitation raised serum ALT, AST and LDH by roughly two to eight fold and produced hepatocyte ballooning degeneration and loss of sinusoidal architecture. Hinokitiol at 1.7 mg/kg markedly reduced these enzyme levels at 6 and 24 h after resuscitation, reversed caspase-3 ac…
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