LncRNA ZNF667-AS1 inhibits inflammatory response and promotes recovery of spinal cord injury via suppressing JAK-STAT pathway.
MouseSpinal cord injuryContusionC57BL/6Femalen = 10 mice per group across three groups (sham, spinal cord in…Injection of overexpression lentivirusBefore the injury procedure
Model: Contusion spinal cord injury delivered to the C5 spinous process with an Infinite Horizon device at 80 kdyn
ZNF667-AS1 expression fell progressively after spinal cord injury while JAK2, STAT3 and iNOS rose in a time-dependent manner. Lentiviral overexpression of ZNF667-AS1 produced marked recovery of forelimb grip strength after injury, consistent with suppression of the JAK-STAT pathway and a reduced in…
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