The mTORC1 signaling modulated by intracellular C3 activation in Paneth cells promotes intestinal epithelial regeneration during acute injury.
MouseOtherC57BL/6 wildtypeIntraperitoneal in vivo; added to culture medium in vitro1 mg in vivo; 20 micrograms/mL in intestinal crypt culture6 h after surgery
Model: Surgically induced acute gastrointestinal injury with sham operation as control; ileal crypt culture used in vitro
Acute gastrointestinal injury broke down mucosal integrity and caused regional inflammation. Exogenous C3 alone did not promote epithelial growth but enhanced Paneth cell activity through intracellular activation, which supported intestinal stem cell expansion within crypts. Blocking C3 activation…
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