Therapeutic hypothermia effectively reduces elevated extracellular ascorbate concentrations caused by acute spinal cord injury.
RatSpinal cord injuryUnspecifiedSprague-DawleyMalen = n = 20 for basal measurement; n = 5 per group for injury an…Systemic cooling28 degrees CAfter injury, during the acute phase, with measurements to 60 min post-injury
Model: Acute spinal cord injury with continuous in vivo monitoring of spinal cord extracellular ascorbate by an online electrochemical system
Basal spinal cord ascorbate was 1.85 plus or minus 0.88 micromol/L (n = 20). Ascorbate rose immediately after injury, reaching 2.36 plus or minus 0.65 micromol/L, that is 164.90 plus or minus 7.99 per cent of basal, at 60 min (n = 5). Therapeutic hypothermia at 28 degrees C attenuated this rise, wi…
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