Identification and Modulation of Microenvironment Is Crucial for Effective Mesenchymal Stromal Cell Therapy in Acute Lung Injury.
MouseChemical/toxinGlutathione peroxidase-1 gene delivered before mesenchymal stromal cell adminis…
Model: Three models of acute lung injury induced by acid instillation, mechanical ventilation, or acid instillation followed by mechanical ventilation; parallel in vitro work with human small airway epithelial cells and human mesenchymal stromal cells exposed to plasma from patients with acute respiratory distress syndrome
The three injury models produced distinct lung proteomic profiles. Mesenchymal stromal cells protected against ventilator-induced lung injury but worsened acid-primed injury, with fibrotic development in a lung environment high in IL-6 and fibronectin and low in antioxidant capacity. Correcting the…
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