Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice.
MouseOtherC57BL/6Malen = 165 human participants (41 mild, 59 moderately severe, 30 s…
Model: Experimental acute pancreatitis in mice, compared across antibiotic-treated mice, germ-free mice and mice receiving faecal microbiota transplantation; induction protocol not stated in the abstract
Antibiotic-treated and germ-free mice showed alleviated pancreatic injury after acute pancreatitis induction, whereas subsequent faecal microbiota transplantation exacerbated disease, indicating the microbiota acts as a mediator of severity.
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