Preventive effects of ketone ester BD-AcAc2 on central nervous system oxygen toxicity and concomitant acute lung injury.
MouseOtherGavage (oral)2.5, 5.0 or 10.0 g per kg body weight20 minutes before hyperbaric oxygen exposure
Model: Central nervous system oxygen toxicity and concomitant acute lung injury induced by 600 kPa hyperbaric oxygen exposure
BD-AcAc2 prolonged seizure latency dose-dependently and significantly reduced hyperbaric oxygen-induced increases in brain malondialdehyde, bronchoalveolar lavage protein and lung water.
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