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PRECLINICAL PUBLICATION · 2018

Metal chaperones: a novel therapeutic strategy for brain injury?

Mouse / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 30507321 ↗2018Reported benefit

Metal chaperones: a novel therapeutic strategy for brain injury?

MouseTBIControlled cortical impactC57BL/6MaleAcute post-injury treatment

Model: Controlled cortical impact traumatic brain injury

Acute post-injury PBT2 reduced lesion area, increased neuron number, decreased astrocytosis and normalised Y-maze performance, with effects emerging within days and maintained to 26 days post-injury.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.