A Comparison Between Two Collagen Nerve Conduits and Nerve Autograft: A Rat Model of Motor Nerve Regeneration.
RatOtherSprague-DawleyMalen = 72 rats randomised into 3 groupsSurgical implantation across the 10 mm nerve gapAt the time of nerve transection
Model: Unilateral 10 mm sciatic nerve defect (acute transection injury) repaired at the time of injury
Autograft outperformed both conduits, and the hollow collagen conduit gave better recovery than the polyglycolic acid collagen-filled conduit, with differences in contractile force significant only at 12 weeks.
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