Prevention of Injury-Induced Osteoarthritis in Rodent Temporomandibular Joint by Targeting Chondrocyte CaSR.
Model: Unilateral anterior cross-bite induced by metal tubes fitted to the left maxillary and mandibular incisors (rat tubes 2.5 mm and 4.5 mm long, inside diameters 3 mm and 3.5 mm, the larger tube bent to a 135 degree angle toward the labial side; mouse tubes inner diameter 0.61 mm, thickness 0.3 mm); cross-bite maintained for 2, 4 or 8 weeks in rats and 3 or 7 weeks in mice
Intra-articular NPS2143 significantly blocked cross-bite-induced cartilage thinning, loss of type II collagen and aggrecan and accelerated chondrocyte terminal differentiation, phenocopying chondrocyte Casr knockout, whereas cinacalcet worsened the same parameters without changing plasma parathyroi…
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