A murine model of acute lung injury identifies growth factors to promote tissue repair and their biomarkers.
MouseChemical/toxinLysM-DTR transgenic mice expressing human diphtheria toxin receptor under the lysozyme M promoter; wild-type bone marrow donors
Model: Diphtheria toxin injection into LysM-DTR mice, depleting type II alveolar epithelial cells, alveolar macrophages and bone marrow-derived myeloid cells; untreated mice died within 6 days
Transfer of wild-type bone marrow cells accelerated regeneration of type II alveolar epithelial cells alongside upregulation of several growth factors, and serum metabolites were identified as candidate biomarkers of injury severity.
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