Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure.
MouseChemical/toxinNOD-SCID (nonobese diabetic severe combined immunodeficient)Malen = n=8 per group for olive oil, carbon tetrachloride plus phos…Intravenous (tail vein)2 x 10^6 hepatocyte-like cells in 500 microlitres of phosph…4 hours after carbon tetrachloride administration
Model: Carbon tetrachloride-induced acute liver failure by intraperitoneal injection of 10 percent carbon tetrachloride in olive oil at 1 mL per kg body weight, with a lethal fulminant model at 3 mL per kg
Hepatocyte-like cell transplantation significantly reduced total bilirubin, transaminases and alkaline phosphatase and raised albumin, attenuated hepatocyte necrosis, engrafted in liver parenchyma and raised survival after lethal carbon tetrachloride from 0 of 8 to 6 of 8 mice.
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