Exogenous IL-19 attenuates acute ischaemic injury and improves survival in male mice with myocardial infarction.
MouseIschaemia-reperfusionCardiacC57BL/6MaleIntraperitoneal10 ng per g
Model: Myocardial infarction produced by ligation of the left anterior descending coronary artery, with a parallel in vitro oxygen-glucose deprivation model in cultured neonatal mouse ventricular myocytes
Exogenous interleukin-19 reduced infarct size, apoptosis, oxidative stress and pro-inflammatory cytokines, promoted M2 polarisation and angiogenesis, and preserved cardiac function and improved survival after myocardial infarction.
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