Bone marrow-derived mononuclear cell therapy can attenuate systemic inflammation in rat heatstroke.
Model: Non-exertional heatstroke under medetomidine 0.375 mg per kg, midazolam 2.0 mg per kg and butorphanol 2.5 mg per kg subcutaneously; rectal temperature raised approximately 1.0 degree Celsius every 5 minutes and held at 41.8 plus or minus 0.2 degrees Celsius for 30 minutes, then recovery at 24 degrees Celsius with 35 mL per kg subcutaneous saline to prevent dehydration
Bone marrow-derived mononuclear cells raised 7 day survival from 41.7 percent to 83.3 percent (p=0.021), lowered serum tumour necrosis factor alpha, histone H3 and syndecan-1, and reduced alveolar oedema and glycocalyx loss, although interleukin-6 and interleukin-1 beta reductions were not signific…
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