Protective Effect of PACAP on Ischemia/Reperfusion-Induced Kidney Injury of Male and Female Rats: Gender Differences.
RatIschaemia-reperfusionRenalWistarMale and femaleIntravenousBefore arterial clamping
Model: Unilateral renal artery clamping followed by 24 h, 48 h or 14 day reperfusion
Tubular damage was significantly less severe in PACAP-treated male and female rats than in controls, with cytokine, oxidative stress and antioxidant findings consistent with the histology; females showed less pronounced injury than males in both treated and untreated groups.
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