MEK/ERK/1/2 sensitive vascular changes coincide with retinal functional deficit, following transient ophthalmic artery occlusion.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMaleAt 0, 6 and 24 h following reperfusion
Model: Ophthalmic artery occluded for 2 h using the middle cerebral artery occlusion model, followed by reperfusion
U0126 attenuated the ischaemia-induced increase in endothelin-1 mediated vasoconstriction (151.0 plus or minus 22.0 per cent of 60 mM K versus 212.1 plus or minus 14.7 per cent in untreated) and improved acute retinal function (a-wave 668 plus or minus 73 microvolts versus 560 plus or minus 21 in u…
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