Sicyos angulatus ameliorates acute liver injury by inhibiting oxidative stress via upregulation of anti-oxidant enzymes.
MouseChemical/toxinC57BL/6JMaleOral gavage100 mg/kg and 300 mg/kg30 min before concanavalin A injection
Model: Concanavalin A-induced acute liver injury; single dose of 15 mg/kg concanavalin A injected via the caudal vein, animals killed 6 h later
Pre-treatment dose-dependently lowered plasma alanine aminotransferase and aspartate aminotransferase, hepatic superoxide, apoptosis and neutrophil infiltration and raised MnSOD, catalase and glutathione peroxidase activity, while glutathione reductase, total reactive oxygen species and hydrogen pe…
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