Early and Late Protective Effect of Bone Marrow Mononuclear Cell Transplantation on Radiation-Induced Vascular Dysfunction and Skin Lesions.
MouseRadiationWild-type C57Bl/6Malen = 12 to 15 mice per group across 5 groups; sub-assays n = 3 t…Intramuscular injection around the woundImmediately after irradiation and wounding
Model: Cutaneous radiation injury: single local 20 Gy gamma exposure at 1.5 Gy/min from a 1.25 MeV collimated cobalt-60 source to a 2 cm by 4 cm dorsal skin field, followed immediately by an 8 mm full-thickness dorsal punch wound left uncovered
A single BMMNC injection increased re-epithelialisation and reduced scar size at day 7 and restored collagen density, fibre diameter, leukocyte rolling velocity and vascular segment number at days 7 and 60 without amplifying acute inflammation, although MCP-1 mRNA, CD45 labelling and vascular perme…
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