Niacin Pretreatment Attenuates Ischemia and Reperfusion of Pancreas-induced Acute Pancreatitis and Remote Lung Injury Through Suppressing Oxidative Stress and Inflammation and Activation of SIRT1.
RatIschaemia-reperfusionOther / unspecifiedSprague-DawleyMale300 mg/kg per dayPre-treatment on the 4 consecutive days before the study
Model: Pancreatic ischaemia by occlusion of both the gastroduodenal and splenic arteries for 120 min followed by 240 min reperfusion
Niacin pre-treatment reduced pancreatic and remote lung injury, attenuated pulmonary oxidative stress and inflammation, protected pulmonary barrier function and restored SIRT1 mRNA expression relative to untreated ischaemia-reperfusion animals.
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