Analgesic effects of the novel alpha2delta ligand mirogabalin in a rat model of spinal cord injury.
RatSpinal cord injuryCompressionSprague-DawleyMaleOral2.5, 5 or 10 mg/kg28 days after spinal cord injury
Model: Acute compression of the spinal cord at the T6/7 level with a microvascular clip; testing 28 days after injury
A single oral dose of mirogabalin significantly raised the paw withdrawal threshold and the paw withdrawal threshold area under the curve relative to control, with effects still significant at 6 to 8 h after administration.
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