MiR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice.

MiR-590-3p Attenuates Acute Kidney Injury by Inhibiting Tumor Necrosis Factor Receptor-Associated Factor 6 in Septic Mice.

Model: Lipopolysaccharide-induced sepsis with acute kidney injury; in vitro lipopolysaccharide-treated podocytes

Adenoviral miR-590-3p markedly improved survival and attenuated lipopolysaccharide-induced acute kidney injury, and in vitro miR-590-3p gain of function blocked podocyte growth inhibition, apoptosis and inflammatory overactivation by targeting TRAF6.

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