Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis.
RatChemical/toxinWistarMalen = 40 rats divided into four groups
Model: Acute hepatic injury and hepatic encephalopathy induced by high-dose paracetamol; dose not stated in the abstract
Alogliptin and silymarin both reversed most paracetamol-induced hepatotoxicity, apoptosis and inflammation markers and improved memory performance, with alogliptin more effective at reducing TGF-beta 1, alpha smooth muscle actin, TNF-alpha and alkaline phosphatase and increasing percentage alternat…
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