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PRECLINICAL PUBLICATION · 2018

A new function for Prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury.

Mouse / TBI

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 30391355 ↗2018Reported benefit

A new function for Prokineticin 2: Recruitment of SVZ-derived neuroblasts to the injured cortex in a mouse model of traumatic brain injury.

MouseTBIUnspecifiedC57BL/6MaleCortical injection

Model: Cortical traumatic brain injury in mice

Subventricular zone cells migrated to the injured cortex after traumatic brain injury, a PROK2 receptor antagonist reduced the number of subventricular zone cells reaching the injured cortex, and recombinant PROK2 injected into uninjured cortex attracted subventricular zone cells.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.