A nonglucocorticoid steroid analog of methylprednisolone duplicates its high-dose pharmacology in models of central nervous system trauma and neuronal membrane damage.
MixedTBIClosed-head / concussionMaleU-72099E up to 100 mg/kg/day; methylprednisolone 30 mg/kg/d…
Model: Concussive head injury in mice, plus in vitro lipid peroxidation-induced membrane damage in rat brain synaptosomes
U-72099E showed no glucocorticoid activity, with no suppression of body weight gain or thymic involution at up to 100 mg/kg/day and no suppression of adrenocorticotropin secretion at 10^-5 M or lower, whereas methylprednisolone 30 mg/kg/day completely inhibited body weight gain and reduced thymus w…
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