A Dual-Function Antibiotic-Transporter Conjugate Exhibits Superior Activity in Sterilizing MRSA Biofilms and Killing Persister Cells.
MouseWoundWild-type C57BL/6MaleTopical into the wound under an occlusive Tegaderm dressing10 microlitres of a 0.05 per cent solution24 h after infection
Model: Excisional wound biofilm infection: 6 mm biopsy punch dorsal excision under 3 per cent isoflurane, inoculated with 10 microlitres of PBS containing MRSA USA300 LAC, covered with an 8 mm Finn Chamber sealed with Tegaderm and infected for 24 h before treatment
A single topical 0.05 per cent V-r8 application eliminated 97 per cent of biofilm-associated MRSA, matched 2 per cent fusidic acid at a 40-fold lower percentage solution and was around 6-fold more efficacious than equal-percentage vancomycin, with no dermal necrosis or apoptosis at 3 days.
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