Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats.
RatChemical/toxinSprague-DawleyWithin 1 h after exposure
Model: Bromine inhalation exposure with resulting acute cardiac injury; exposure concentration and duration not stated in the retrieved text. A separate experiment injected 2-bromohexadecanal into the left ventricular cavity of a normal rat
Bromine inhalation caused acute cardiac ultrastructural damage, biomarker rises and left ventricular systolic and diastolic dysfunction, and MDL28170 given within 1 h of exposure significantly decreased left ventricular calpain activity and acute mortality.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.