Traumatic brain injury-induced neuronal damage in the somatosensory cortex causes formation of rod-shaped microglia that promote astrogliosis and persistent neuroinflammation.
MouseTBIFluid percussionC57BL/6MaleOral, in diet1,200 mg/kg formulated in AIN-76A chowBefore injury (microglia eliminated prior to TBI)
Model: Midline fluid percussion injury (diffuse TBI)
Microglial elimination by PLX5622 did not affect cortical neuron axotomy induced by TBI, but attenuated rod microglial formation and astrogliosis and prevented both acute and chronic cortical inflammatory gene responses.
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