YiQiFuMai lyophilized injection attenuates particulate matter-induced acute lung injury in mice via TLR4-mTOR-autophagy pathway.
MouseChemical/toxinTail vein injection (intravenous)0.33, 0.67 and 1.34 g/kg30 min after intratracheal instillation of particulate matter
Model: Intratracheal instillation of Standard Reference Material 1648a particulate matter, 50 mg/kg body weight
YQFM markedly reduced lung pathological injury and the lung wet to dry weight ratio after particulate matter instillation. It inhibited myeloperoxidase activity, lowered IL-1beta and TNF-alpha, reduced nitric oxide and total protein in lavage fluid and attenuated the rise in lavage lymphocytes. Mec…
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