Linagliptin protects rat carotid artery from balloon injury and activates the NRF2 antioxidant pathway.
RatOtherWistarMaleOral (in 5% sodium carboxymethyl cellulose)1, 2 and 3 mg/kg/dayStarted 2 weeks before the operation and continued for 4 weeks after balloon in…
Model: Carotid artery balloon (angioplasty) injury
Linagliptin attenuated neointima formation after balloon injury without altering body weight or blood glucose. It reduced TNF-alpha, IL-1beta and IL-6 dose dependently, lowered malondialdehyde and restored superoxide dismutase and glutathione peroxidase activity. Treatment decreased KEAP1 and incre…
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