Attenuation of Lipopolysaccharide-Induced Acute Lung Injury by Cyclosporine-A via Suppression of Mitochondrial DNA.
MouseEndotoxin/LPSC57BL/6Malen = n=6 per group, 24 totalIntraperitoneal2.5 mg/kg (low dose) and 25 mg/kg (high dose)15 min after lipopolysaccharide administration
Model: Lipopolysaccharide-induced acute lung injury (intraperitoneal LPS 10 mg/kg)
Both doses of cyclosporine-A reduced the lipopolysaccharide-induced rise in lung wet to dry ratio, myeloperoxidase activity, lavage total cells and neutrophils. Only the 25 mg/kg dose significantly improved the histological lung injury score and reduced lavage total protein. Plasma mitochondrial DN…
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