Adalimumab mitigates ovarian ischemia-reperfusion injury in rats by regulating oxidative stress, apoptosis and resolution of inflammation.
RatIschaemia-reperfusionOther / unspecifiedWistar AlbinoFemalen = 40 rats in total, four groups
Model: Bilateral ovarian torsion-detorsion (ischaemia-reperfusion)
Adalimumab reduced tissue total oxidant status, oxidative stress index and nitric oxide, increased tissue total antioxidant status, lowered inflammation, vascular congestion and haemorrhage, and significantly decreased the apoptotic index. Serum oxidative stress markers and tissue malondialdehyde d…
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