Microglial Calcium Release-Activated Calcium Channel Inhibition Improves Outcome from Experimental Traumatic Brain Injury and Microglia-Induced Neuronal Death.
MouseTBIUnspecifiedC57BL/6Male
Model: Experimental brain trauma; parallel in vitro BV2 microglial activation by Toll-like receptor agonists or interferon gamma
CM-EX-137 reduced lesion size, brain haemorrhage and neurological deficits with decreased microglial activation and lower inducible nitric oxide synthase, Orai1 and STIM1 levels. In vitro it reduced nitric oxide release, inducible nitric oxide synthase expression and agonist-induced intracellular c…
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