Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure.

Dysregulated bile acid signaling contributes to the neurological impairment in murine models of acute and chronic liver failure.

Model: Azoxymethane-induced acute liver failure and streptozotocin plus high fat diet-induced chronic liver disease

SC-435 reduced bile acid and ammonia concentrations in blood and brain and alleviated liver and brain damage in both the azoxymethane acute liver failure and streptozotocin high fat diet chronic liver disease models. Budesonide, an ASBT activator, induced liver and brain damage in normal mice and w…

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