Neuroinflammation, oxidative stress, and blood-brain barrier (BBB) disruption in acute Utah electrode array implants and the effect of deferoxamine as an iron chelator on acute foreign body response.
RatTBIUnspecifiedSprague DawleyMalen = n=5 per group for the liver and kidney function safety test…Intraperitoneal100 mg/kg in sterile waterFirst injection one hour after implantation surgery
Model: Implantation of a non-functional 4 x 4 Utah microelectrode array into the somatosensory cortex, causing vascular and blood-brain barrier disruption and a foreign body response
Utah array implantation elicited acute oxidative stress, neuroinflammation and neurovascular unit disruption. Deferoxamine was evaluated as an iron chelator intended to reduce free iron in the parenchyma; the abstract reports the evaluation without stating a single overall direction of effect acros…
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