Preparation and protective effects of 1,8-cineole-loaded self-microemulsifying drug delivery system on lipopolysaccharide-induced endothelial injury in mice.
MouseEndotoxin/LPSOral (used for the acute toxicity assay; median lethal dose 2998.9 mg/kg)
Model: Lipopolysaccharide-induced vascular endothelial injury in mice
CIN-SMEDDS inhibited IL-1beta, IL-6 and IL-8 with a simultaneous increase in IL-10 in lipopolysaccharide-treated mice and attenuated endothelial injury on histology, with effects associated with NF-kappaB and PPAR-gamma signalling.
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