Leonurine ameliorates adriamycin-induced podocyte injury via suppression of oxidative stress.

Leonurine ameliorates adriamycin-induced podocyte injury via suppression of oxidative stress.

Model: Adriamycin (doxorubicin)-induced nephropathy with podocyte injury in mice, with parallel experiments in cultured human podocytes

Leonurine significantly prevented early kidney damage, macrophage infiltration and proteinuria in adriamycin nephropathy, and suppressed podocyte injury and reactive oxygen species production both in vivo and in cultured human podocytes.

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