Kynurenic Acid Protects against Thioacetamide-Induced Liver Injury in Rats.
RatChemical/toxinWistarMalen = n=8 per group, four groupsIntraperitoneal500 mg/kg body weight30 minutes before thioacetamide administration (pretreatment)
Model: Single intraperitoneal thioacetamide injection (150 mg/kg body weight) inducing acute liver injury, assessed 24 h later
Kynurenic acid pretreatment prevented the thioacetamide-induced rise in AST (316.3 to 185.6 U/L) and ALT (90.2 to 57.8 U/L), restored liver kynurenic acid content, partly preserved thiol groups (36.3 to 61.5 mmol/mg protein), abolished the increases in MDA + 4-HNE, myeloperoxidase and TNF-alpha (39…
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