The healing effect of hydrogen-rich water on acute radiation-induced skin injury in rats.
RatRadiationWistarMalen = 60 rats randomised into 3 groups of 20; 4 rats per group sa…Topical spray/atomisation onto the wound1.0 ppm or 2.0 ppm hydrogen-rich water, 1 ml per applicationStarted after wound formation, approximately 35 days after the single 44 Gy irr…
Model: Single local irradiation of buttock skin (3 cm x 4 cm field, unirradiated areas lead shielded) with a 6 MeV electron beam at 400 cGy/min for 11 min to a total dose of 44 Gy, producing acute radiation dermatitis with erosion and ulceration by about day 35
Complete healing occurred at 34.92 +/- 2.23 days with distilled water, 31.76 +/- 2.04 days with 1.0 ppm HRW and 26.24 +/- 1.60 days with 2.0 ppm HRW, with significantly higher healing rates at weeks 2 to 4 (p<0.05). MDA at week 4 was lower and SOD activity higher in both HRW groups, serum IL-6 was…
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