ERK activating peptide, AES16-2M promotes wound healing through accelerating migration of keratinocytes.
MouseWoundBALB/c wild-type and BALB/c-nudeFemaleTopical gel applied to the wound0.5 microgram per wound in 50 microlitres of 20% Pluronic F…Applied to the wound area after punch wounding
Model: Acute full-thickness 10 mm diameter dorsal excisional punch wound under avertin anaesthesia; supporting in vitro HaCaT scratch and human dermal fibroblast transwell migration assays
Wound size decreased steadily with AES16-2M, significantly versus control peptide on days 2 to 8 in BALB/c wild-type mice and on days 2, 3 and 9 in BALB/c-nude mice. At day 4 the treated group showed multiple epithelial layers at the wound edge, increased granulation tissue, increased CD31 and a si…
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